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April 29, 2011 -- Women with low vitamin D levels may accept an added accident for the best advancing breast cancers, new analysis suggests.
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Several beforehand studies accept appropriate a articulation amid low vitamin D levels and breast blight risk. But the new abstraction is amid the aboriginal to appraise vitamin D dearth and poor prognosis.
Researchers from the University of Rochester Medical Center advised vitamin D levels in 155 breast blight patients in the months afore or afterwards they had anaplasty to amusement their disease.
They begin suboptimal vitamin D levels to be awful predictive of the attendance of biological markers associated with added advancing tumors.
Women in the abstraction with triple-negative tumors, which do not acknowledge to hormone treatments, were about three times added acceptable to accept suboptimal vitamin D levels as women with added breast cancers.
Triple-negative tumors are difficult to amusement and they tend to accept a worse cast than added breast cancers.
“We consistently saw lower vitamin D levels in breast blight patients with poor anxiety markers,” abstraction researcher Luke Peppone, PhD, tells WebMD.
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The abstraction participants had anaplasty for breast blight amid January 2009 and September 2010. Based on testing conducted aural a year afore or afterwards surgery, the patients were advised to accept either optimal (32 ng/mL or greater) or suboptimal (less than 32 ng/mL) vitamin D levels.
All patients additionally had a almost new analysis advised to adumbrate their accident of ceremony based on the attendance of genes that accept been articular with breast cancer.
The advisers appear a able alternation amid abbreviating vitamin D levels and accretion array on the predictive test.
African-American women and premenopausal women were added acceptable to accept suboptimal vitamin D levels than older, white women.
The abstraction is appear online in the Annals of Surgical Oncology.
While the analysis does not prove that low vitamin D levels access outcomes in women who advance breast cancers, Peppone says added abstraction is absolutely warranted.
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American Blight Society Agent Arch Medical Administrator Len Lichtenfeld, MD, agrees.
“The vitamin D analysis as a accomplished is absolutely intriguing, but we accept abstruse abounding times afore that what appears arresting doesn’t consistently authority up back appropriately studied,” he tells WebMD.
The absolute bloom action accumulation Institute of Medicine (IOM) afresh advised in on vitamin D and cancer, calling the affirmation that vitamin D prevents breast and added cancers “inconsistent and inconclusive.”
Vitamin D is produced by the anatomy from the sun’s rays. It is begin in salmon, tuna, and added adipose angle and is added to dairy products. But experts accede that it would be actual difficult to get abundant vitamin D from aliment sources alone.
The console recommended a circadian assimilation of 600 all-embracing units (IU) from age 1 to 70 and 800 IU over age 70.
“The [IOM] experts did not abolish the abstraction that vitamin D may accept a role in preventing blight or affecting its advance already it develops,” Lichtenfeld says. “They accustomed that the analysis is trending in this direction, but did not feel that it met the beginning for absolute that a cause-and-effect accord exists.”
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Breast blight specialist Sharon M. Rosenbaum Smith, MD, of St. Luke’s-Roosevelt Medical Center in New York, agrees that the new abstraction deserves follow-up.
“We are seeing abstraction afterwards abstraction suggesting a articulation amid vitamin D and breast cancer,” she says. “But what that exact articulation is has yet to be determined.”
SOURCES:
Peppone, L.J. Annals of Surgical Oncology, online, April 29, 2011.
Luke Peppone, PhD, analysis abettor assistant of radiation oncology, University of Rochester Medical Center, N.Y.
Sharon M. Rosenbaum Smith, MD, Comprehensive Breast Center, St. Luke’s-Roosevelt Medical Center, New York.
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Len Lichtenfeld, MD, agent arch medical officer, American Blight Society.
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