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factor v leiden icd 10
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The American Journal of Gastroenterology 102, 338–343 (1 February 2007) | doi:10.1111/j.1572-0241.2006.00974.x
Charles N Bernstein , Michael Sargent , Hans L Vos & Frits R Rosendaal
BACKGROUND: Patients with Crohn's ache (CD) and ulcerative colitis (UC) accept a three- to fourfold greater accident of venous occlusion compared with the accepted population. We aimed to actuate if patients with CD and UC had a greater likelihood of mutations in genes that admission array risk, in a population-based case–control study. METHODS: Subjects were fatigued from the University of Manitoba IBD Research Registry and controls were fatigued from Manitoba Health's authoritative database. Cases (CD, N |[equals]| 327; UC, N |[equals]| 165) and controls (N |[equals]| 412) underwent venipuncture. DNA was antiseptic from accomplished blood. Genotypes for wild-type and accepted mutations that accept been associated with venous occlusion for anniversary of Factor II (prothrombin) (G20210A), Factor V (G1691A |[lsquo]|Leiden|[rsquo]|), methylenetetrahydrofolate reductase (MTHFR, C677T), and Factor XIII (val34leu) were assessed. RESULTS: A absolute of 1.5|[percnt]| and 6.1|[percnt]| were heterozygous for Factor II and Factor V variants, respectively, after differences amid cases and controls. Only one accountable was homozygous for Factor V Leiden (and none were homozygous for Factor II mutation). Although some differences were empiric amid cases and controls in the prevalence of MTHFR C677T (decrease in aberrant allele carriership in UC) and FXIII val34leu (increase in bifold aberrant allele carriership in CD), these did not explain an balance accident of thrombosis. Age, sex, or ache phenotypes were not associated with prothrombotic genotypes. CONCLUSIONS: While there was a hardly greater prevalence of Factor XIII alteration carriership in CD, we did not acquisition that gene mutations for these four accepted factors could explain the greater accident of venous occlusion in CD and UC. The American Journal of Gastroenterology (2007) 102, 338–343; doi:10.1111/j.1572-0241.2006.00974.x
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