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‘Foods that are affluent in potassium like assistant and avocado reduces vascular calcification, anticipate arterial acerbity and anticipate both affection and branch disease.’
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The abstraction was agitated out in the atherosclerosis-prone abrasion model. Mice that abridgement apolipoprotein E are at a college accident of developing cardiovascular ache back fed a high-fat diet.
The diet assorted in the concentrations of potassium - low (0.3%), accustomed (0.7%) and aerial (2.1%). Mice fed a low-potassium diet had a cogent access in vascular calcification. However, mice fed a high-potassium diet had clearly inhibited vascular calcification.
Arterial acerbity was abstinent application beating beachcomber velocity. Mice on the low-potassium diet had added arterial acerbity and a high-potassium diet had decreased stiffness.
Arterial cross-sections in cultures were apparent to three altered concentrations of potassium, based on accustomed physiological levels of potassium in the blood. The analysis aggregation begin a absolute aftereffect of the potassium on arterial calcification aural arterial rings. Arterial rings in low-potassium had clearly added calcification, while high-potassium inhibited aortic calcification.
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"The allegation accept important translational potential. Since they authenticate the account of able potassium supplementation on blockage of vascular calcification in atherosclerosis-prone mice, and the adverse aftereffect of low potassium intake," said Dr Paul Sanders, assistant of nephrology in the UAB Department of Medicine.
The aggregation begin that added comestible potassium levels can assure adjoin vascular calcification and aortic stiffness.
The allegation of the abstraction appearance how vascular bland beef beef in the arteries adapt vascular calcification. The abstraction emphasizes the charge to accede comestible assimilation of potassium in the blockage of atherosclerosis. It additionally provides new targets for abeyant therapies to anticipate or amusement atherosclerotic vascular calcification and arterial stiffness.
Mechanism of Potassium in Preventing Vascular CalcificationLow potassium levels in the ability media added calcification of vascular bland beef cells. Previous studies accept apparent that calcification of vascular bland beef beef resembles the adverse of cartilage cells, which leads to the transformation of bland beef beef into bone-like cells.
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The UAB analysis aggregation activated the aftereffect of growing vascular bland beef beef in low-potassium corpuscle culture. They begin that low-potassium levels answer the announcement of several gene markers that are hallmarks of cartilage cells, but decreased the announcement of vascular bland beef corpuscle markers. This suggests that the transformation of the vascular bland beef beef into bone-like beef beneath low-potassium conditions.
Low-potassium levels animated intracellular calcium in the vascular bland beef beef via a potassium carriage approach alleged the entering rectifier potassium channel. This apparatus was accompanied by activation of several accepted after mediators, including protein kinase C and the calcium-activated cAMP acknowledgment element-binding protein (CREB).
CREB activation added autophagy in low-potassium levels. Autophagy plays an important role in mediating calcification of vascular bland beef beef induced by the low-potassium condition. The analysis aggregation acclimated autophagy inhibitors and begin that blocking autophagy can block calcification.
The analysis aggregation activated the roles of the CREB activation and autophagy signals again activated in the abrasion avenue array and in abrasion models with low, accustomed or aerial levels of potassium in the ability or diet. The after-effects abutment the basic role for potassium to adapt vascular calcification through calcium signaling, CREB, and autophagy.
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Food Sources of PotassiumPotassium is a micronutrient that assists in a ambit of capital anatomy functions such as claret pressure, accustomed baptize balance, beef contractions, digestion, affection accent and pH balance.
Some fo the acceptable sources of potassium are banana, avocado, apricots, artichokes, cantaloupe, potatoes, prunes, pumpkin, spinach, candied potatoes and tomatoes.
Reference:
Yong Sun, Chang Hyun Byon, Youfeng Yang, Wayne E. Bradley, Louis J. Dell'Italia, Paul W. Sanders, Anupam Agarwal, Hui Wu, Yabing Chen. Comestible potassium regulates vascular calcification and arterial stiffness. JCI Insight, (2017) DOI: 10.1172/jci.insight.94920
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Source: Medindia
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