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acute on chronic respiratory failure icd 10
What's new apropos astute respiratory ache syndrome? Find out in this easy-to-navigate accumulating of contempo MEDLINE abstracts aggregate by the editors at Medscape Analytical Care.
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Vieillard-Baron A, Prin S, Chergui K, Page B, Beauchet A, Jardin FIntensive Affliction Med. 2003 Aug 16 [Epub advanced of print]
Objective: Evaluation of low-flow pressure-volume bend at the bedside in ARDS, as an aid to appraise application produced by complete end-expiratory burden (PEEP).Materials and Methods: Low-flow pressure-volume bend at the bedside were acquired on the aboriginal day of respiratory abutment in 54 alternating pulmonary astute respiratory ache affection (ARDS) patients (49 of whom had pneumonia) advised amid April 1999 and June 2002. From the bend acquired at aught end-expiratory burden (ZEEP), we bent manually the lower inflexion point (LIP). By superimposing the pressure-volume bend at ZEEP and at PEEP, we evaluated application acquired at a connected adaptable burden of 20 cm H2O.Results: We empiric 2 altered types of loops, according to the arrangement of the aggrandizement limb. In blazon 1 (38 cases), the aggrandizement limb was characterized by an inflexion zone, consistent from a accelerating or a abrupt advance in compliance. In blazon 2 (16 patients), the aggrandizement limb was around linear, afterwards cogent advance in acquiescence during inflation, which remained decidedly low (26±9 cm H2O). Use of a low PEEP (6±2 cm H2O) produced a abundant application in type-1 patients (74±53 ml), which was hardly bigger by a college PEEP (89±54 ml). In blazon 2, application produced by PEEP was decidedly lower (48±26 ml, P = .006).Conclusion: Pressure-volume bend at bedside accepted that a low PEEP was acceptable to access application in ARDS. This abstraction additionally abundant a accumulation of pulmonary ARDS patients announcement a clearly bargain compliance, in whom application acquired by PEEP was limited.
Anton N, Joffe KM, Joffe ARIntensive Affliction Med. 2003 Aug 16 [Epub advanced of print]
Objective: To (a) call the acquaintance with high-frequency cadence (HFO) in accouchement with astute respiratory ache affection (ARDS) above to accepted ventilation; (b) analyze empiric adaptation to that predicted by pediatric bloodshed scores; and (c) actuate if oxygenation basis changes during HFO can adumbrate survival.Design: Retrospective, empiric study.Setting: A university hospital pediatric accelerated affliction unit.Patients: Nineteen accouchement with ARDS (PaO2/FIO2 < 200) above to accepted blast advised with HFO from January 1995 to September 1996.Interventions: None.Measurements and Results: The afterward were recorded: demographic, arterial claret gas and chase variables at the time credibility 0, 6, 12 and 24 h afterwards the alpha of HFO; PRISM in the aboriginal 24 h of acceptance and pediatric respiratory abortion and assorted agency arrangement abortion array on the day of starting HFO. The bloodshed bulk was 26% (5/19). The adaptation was bigger than predicted by the Pediatric Respiratory Abortion account (P < .01). None of the array differentiated survivors from non-survivors (P > .25). There was no cogent change in oxygenation basis over the aboriginal 24 hours (P > .18). Of patients with an antecedent oxygenation basis college than 20 who did not accept at atomic a 20% abridgement in oxygenation basis by the time 6 hours, 6/9 (67%) survived (sensitivity 75%, specificity 57%).Conclusions: Adaptation in pediatric ARDS patients advised with HFO could not be predicted application several aftereffect array or the oxygenation basis (in the aboriginal 24 hours). Adaptation was decidedly bigger than predicted by the Pediatric Respiratory Abortion score. A -to-be randomized controlled balloon of HFO in ARDS is warranted.
Bindl L, Buderus S, Dahlem P, et alIntensive Affliction Med. 2003 Aug 15 [Epub advanced of print]
Male gender predisposes to astringent sepsis and catchbasin shock. This aftereffect has been ascribed to college levels of testosterone. The ESPNIC ARDS database was searched to actuate if there was affirmation of a agnate macho advantage in astringent sepsis in prepubertal patients in animosity of low levels of macho sex hormones at this age. A complete of 72 patients above neonatal age up to 8 years of age with sepsis were identified. The male/female (M/F) arrangement was 1.7 (1.0;2.7) and differed decidedly from non-septic ARDS patients in this age accumulation [n = 209; M/F = 1.0 (0.8;1.3)]. The accomplished M/F-ratio was empiric in the aboriginal year of life. The gender-ratio was the aforementioned as appear in developed patients with sepsis. In breed amid 1 ages and 12 months of age, the arrangement was 2.8 (1.2;6.1) (Chi2 = 5.6; P < .01), in accouchement from 1 year to 8 years of age it was 1.2 (0.7;2.2) (n.s.). In a subgroup of patients with astringent sepsis or catchbasin shock, acquired by added bacilli than Neisseria meningitidis, the M/F-ratio was 2.1 (1.2;3.6) (Chi2 = 4.9; P < .05); while in patients with meningococcal sepsis (n = 20), the M/F-ratio was 1.0 (0.4;2.3). In prepubertal ARDS patients with sepsis, an added abundance of macho patients is found, commensurable to adults. No macho advantage exists in patients with ARDS due to meningococcal catchbasin shock. Since levels of testosterone and added sex hormones are acutely low at this age, we achieve that factors others than testosterone are circuitous in the macho advantage in astringent sepsis.
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Petrucci N, Iacovelli WCochrane Database Syst Rev. 2003;(3):CD003844
Background: Patients with astute respiratory ache affection (ARDS) and astute lung abrasion (ALI) crave automated ventilatory support. ALI/ARDS is added complicated by ventilator-induced lung injury. Lung-protective blast strategies may advance to bigger survival.Objectives: To appraise the furnishings of blast with lower flat aggregate (Vt) on anguish and bloodshed in adults patients afflicted by ALI/ARDS. A accessory cold was to actuate whether the allegory amid low and accepted Vt is altered if a plateau airway burden of greater than 30 to 35 cmH2O was used.Search Strategy: We searched The Cochrane Central Register of Controlled Trials (CENTRAL), The Cochrane Library affair 3, 2002; MEDLINE (1966 to June 2002); EMBASE and CINAHL (1982 to June 2002); accelerated affliction journals and appointment proceedings; databases of advancing research, advertence lists and 'grey literature'.Selection Criteria: Randomized trials comparing blast application lower Vt and/or low airway active burden (plateau burden 30 cm H2O or less), consistent in Vt of 7 ml/kg or beneath against blast that uses Vt in the ambit of 10 to 15 ml/kg, in adults (16 year-old or greater).Data Accumulating and Analysis: Two reviewers apart adjourned balloon affection and extracted data. Wherever appropriate, after-effects were pooled. Fixed and accidental furnishings models were applied.Main Results: Bristles trials, involving 1202 patients, were eligible. The assay for adverse gave a P-value of 0.12. Blast with lower Vt was associated with a decreased bloodshed at the end of the chase up aeon for anniversary trial: 216/605 (35.7%) against 249/597 (41.7%), about accident (RR) 0.85 (CI 0.74 to 0.98). The aftereffect of the action was not statistically cogent back a accidental furnishings archetypal was used: RR 0.91 (CI 0.72 to 1.14). Bloodshed at day 28 was decidedly bargain by lung-protective ventilation: RR 0.74 (CI 0.61 to 0.88). The allegory amid low and accepted Vt was not decidedly altered if a plateau burden beneath than or according to 31 cm H2O in ascendancy accumulation was used: RR 1.13 (CI 0.88 to 1.45). There was bereft affirmation about anguish and abiding outcomes.Reviewer's Conclusions: Analytic heterogeneity, such as altered lengths of chase up and college plateau burden in ascendancy accoutrements in 2 trials accomplish the estimation of the accumulated after-effects difficult. Bloodshed is decidedly bargain at day 28 and the furnishings on abiding bloodshed are uncertain, although the achievability of a clinically accordant account cannot be excluded. There is no affirmation that low Vt blast is benign in patients area hypercapnia is potentially harmful.
Johnston CJ, Rubenfeld GD, Hudson LDChest. 2003;124:653-659
Study Objectives: The purpose of this abstraction was to actuate the complete aftereffect of age on the accident of developing ARDS in patients with trauma.Design: -to-be accomplice study.Setting: Level I agony center.Measurements and Results: A complete of 4,020 afterwards agony patients who were greater than 12 years of age were articular through the Harborview Medical Centermost Agony Registry over a 3-year period. During this time, 484 of the agony patients (12%) developed ARDS, as articular by the Harborview Medical Centermost ARDS Registry. Patients who developed ARDS were, on average, beforehand (mean [± SD] age, 44.0 ± 18.8 vs 40.2 ± 20.0 years, respectively; P < .0001) and had college abrasion severity array (23.7 ± 11.3 vs 18.0 ± 10.3, respectively; P < .0001) than agony patients who did not advance ARDS. The best unadjusted allowance arrangement for developing ARDS was 2.93 (95% aplomb interval, 1.91 to 4.50) for the accumulation 60 to 69 years of age compared to the accumulation 13 to 19 years of age. Patients age-old ≥ 80 years had an according accident of developing ARDS compared to those age 13 to 19 years.Conclusions: Age approved a circuitous accord with accident for ARDS development. Beforehand patients showed added college risks for ARDS development up to 60 to 69 years of age, back the accident for ARDS declined. We assured that beforehand patients are at decidedly greater accident of developing ARDS back compared to adolescent patients, while the oldest patients may be at beneath risk.
Mokart D, Guery BP, Bouabdallah R, et alChest. 2003;124:644-652
Study Objectives: Neutrophils generally accept been circuitous in the pathophysiology of ARDS. However, accurate ARDS has been declared in patients with astringent neutropenia, suggesting the attendance of added abeyant mechanisms that are amenable of this syndrome. Alveolar macrophages (AMs) could be circuitous in the development of ARDS, and so we absitively to abstraction AM activation in neutropenic patients.Patients: We advised a -to-be abstraction and enrolled 2 subgroups of afterwards patients (group A, 18 patients; accumulation B, 22 patients) with catchbasin ARDS. In the aboriginal period, 7 of 18 patients were neutropenic, and in the additional aeon 10 of 22 patients were neutropenic. All neutropenic patients were advised with granulocyte colony-stimulating agency (G-CSF).Measurements and Results: In accumulation A, bronchoalveolar lavage (BAL) aqueous samples were analyzed for cogwheel and complete corpuscle counts, and alveolar activation brand announcement (ie, animal corpuscle antigen [HLA]-DR locus) was determined. Basal and lipopolysaccharide (LPS)-stimulated assembly of bump afterlife factor, interleukin (IL)-1beta, IL-6, and IL-10 was evaluated in accumulation B. In neutropenic patients, the BAL aqueous complete corpuscle calculation and the neutrophil complete calculation were decidedly lower compared to those in non-neutropenic patients (P = .029 and P = .046, respectively). HLA-DR announcement on AMs was decidedly decreased (P = .016), and the allotment of AMs cogent HLA-DR was additionally decidedly lower (P = .041). In neutropenic patients, the beggarly allotment of AMs cogent HLA-DR was decidedly lower in asleep patients compared to survivors (30 ± 7 vs 43 ± 1, respectively; P = .047). Basal AMs appear cytokines was commensurable amid the 2 groups; however, LPS dispatch yielded a deactivation of AMs in neutropenic patients.Conclusion: These after-effects advance a deactivation and/or hypoactivation of AMs in catchbasin ARDS patients. This deactivation/hypoactivation could be affiliated to the use of G-CSF as this atom has been apparent to accomplish a down-regulation of HLA-DR expression.
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Prat G, Renault A, Tonnelier JM, et alIntensive Affliction Med. 2003 Aug 6 [Epub advanced of print]
Objective: To appraise the furnishings of the humidification accessory on respiratory, hemodynamic and gas barter ambit in astute respiratory ache affection (ARDS) patients.Design: A -to-be accessible study.Setting: A medical accelerated affliction assemblage of a university hospital. PATIENTS. Astute respiratory ache affection patients, with hypercapnia (PaCO2 > 60 mmHg).Intervention: A accelerating abridgement of the humidification arrangement asleep amplitude (DSh). The afterward bristles altitude were activated sequentially: 1. calefaction and damp exchanger (internal aggregate = 95 ml) with a tracheal closed-suction arrangement (internal aggregate = 25 ml; complete DSh = 120 ml); 2. calefaction and damp exchanger (internal aggregate = 45 ml) with the closed-suction arrangement (DSh = 70 ml); 3. calefaction and damp exchanger (internal aggregate = 25 ml) with the closed-suction arrangement (DSh = 50 ml); 4. acrimonious humidifier with the closed-suction arrangement (DSh = 25 ml); and 5. acrimonious humidifier abandoned (DSh = 0 ml). Recordings were performed at baseline and every 30 account afterwards anniversary bogus dead-space reduction. All ventilatory settings remained connected during the altitude periods.Results: Ten ARDS patients were included. A cogent PaCO2 abatement was empiric at anniversary humidification arrangement dead-space reduction, compared to baseline: PaCO2 = 80.3 ±20 mmHg at DSh(120) compared to PaCO2 = 63.6 ±13 mmHg at DSh(0) (P < .05). No changes were empiric for hemodynamic and ventilatory ambit amid the altered humidification devices.Conclusion: Bogus airway dead-space abridgement allows a cogent PaCO2 reduction. Apart of any respiratory automated changes, this actual simple action may be of accent back low flat aggregate blast is acclimated in ARDS patients, and back PaCO2 blurred is warranted.
David M, Weiler N, Heinrichs W, et alIntensive Affliction Med. 2003 Jul 25 [Epub advanced of print]
Objective: This abstraction advised whether ARDS patients, in whom predefined chase settings abort to advance oxygenation and CO2 removal, can be cautiously transitioned to high-frequency oscillatory blast (HFOV), and whether HFOV use is efficacious.Design and Setting: -to-be empiric abstraction in the 14-bed accelerated affliction assemblage of a university hospital.Patients and Participants: 42 patients with ARDS (APACHE II account 28 [IQR 24-37]) and blast time above-mentioned HFOV 3.0 canicule (0.7-9.1).Measurements and Results: Gas barter ambit and chase abstracts were recorded afore and during HFOV assay (-12 h, -6 h, baseline, 10 min, 1 h, 6 h, 12 h, 24 h). Primary endpoints included: a) PaO2/FIO2 arrangement 24 hours afterwards alpha of HFOV assay or the aftermost point of altitude if HFOV concluded aural the aboriginal 24 h; b) HFOV-related complications. Post hoc assay adjourned the accord amid aftereffect and the acknowledgment to HFOV, and amid aftereffect and time of automated blast above-mentioned to HFOV. At baseline the average PaO2/FIO2 arrangement was 95 (IQR 62-129); afterwards 24 h of HFOV the PaO2/FIO2 arrangement had added decidedly to 165 (88-225); alone one accommodating developed a unilateral pneumothorax. Of the 42 patients, 18 (43%) had died by day 30. Subset analyses showed a decidedly college 30-day bloodshed bulk in patients with at atomic 3 canicule of automated blast above-mentioned to HFOV (64%) and in patients afterwards oxygenation advance afterwards 24 h on HFOV (71%).Conclusions: HFOV is an able and safe adjustment to advertise ARDS patients. Abortion to advance oxygenation aural 24 h of HFOV is associated with aerial mortality.
Long Y, Liu DW, Du B, et alZhonghua Jie He He Hu Xi Za Zhi. 2003;26:282-285
Objective: To appraise the bulk of changeless P-V ambit beneath aught end-expiratory burden (ZEEP) in admiration the aftereffect of abiding aggrandizement (SI) on hemodynamics, oxygenation, and alveolar application in patients with astute respiratory ache affection (ARDS).Methods: Changeless P-V ambit was abstinent beneath complete end-expiratory burden (PEEP) in all the patients 2 h afterwards PEEP was applied. Patients who accomplished added than 20% access in PaO2/FiO2 were advised as responders to SI.Results: 1. The changeless P-V curves in responders consistently showed a biconcave arrangement with c-2d ≥ 0 cm H2O (1 cm H2O = 0.098 kpa) and c ≥ 18 cm H2O, while those in non-responders showed a arched arrangement with c-2d < 0 cm H2O or c < 18 cm H2O. 2. Afterwards SI, abatement of Q(s)/Q(t) (P = .006) was begin in responders, but not in non-responders (P = .339). The bulk of recruited aggregate was decidedly college in responders than in non-responders afterwards SI [(241 ± 111) ml vs (29 ± 46) ml, P = .036].Conclusion: The changeless P-V curves beneath ZEEP apparent altered patterns in responders and non-responders to SI in ARDS patients, and may be of bulk in admiration the acknowledgment to SI.
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Fortenberry JD, Meier AH, Pettignano R, Heard M, Chambliss CR, Wulkan MJ Pediatr Surg. 2003;38:1221-1226
Background: Primary alarming abrasion was advised advanced a contraindication for academy of extracorporeal activity abutment because of aerial accident for assiduous or new bleeding. Published acquaintance in adults suggests that extracorporeal film oxygenation (ECMO) can auspiciously abutment agony victims with pulmonary failure. The authors advised their acquaintance with the use of ECMO in pediatric and developed agony patients with astute respiratory ache affection (ARDS) at a children's medical center.Methods: ECMO Centermost annal from 1991 through 2001 (76 children, 8 adults) were advised to analyze all patients with a primary or accessory ICD-9 analytic cipher of post-traumatic ARDS in accession to accurate trauma.Results: Bristles accouchement and 3 adults with alarming abrasion and ARDS accustomed ECMO support. Seven patients were afflicted in motor agent collisions; one accommodating suffered a gunshot anguish to the chest. Accommodating ages ranged from 21 months to 29 years (pediatric median, 4 years; range, 21 months to 18 years). Four patients had pre-ECMO laparotomies, including 3 who appropriate splenectomy. Four patients had alarmist lacerations, 3 had pulmonary contusions, and 1 had a renal contusion. Average blast afore ECMO was 6 canicule (range, 2 to 10). Seven of 8 patients were placed on venovenous (VV) ECMO. Seven patients had cogent bleeding on ECMO. Patients were advised with claret artefact replacement, epsilon-aminocaproic acerbic (EACA), and aprotinin infusions. Surgical action was not appropriate for bleeding. Six patients accustomed hemofiltration. Average time on ECMO was 653 hours (range, 190 to 921 hours). Six of 8 patients all-embracing survived (75%). Four of 5 pediatric patients survived.Conclusions: Accouchement and adults with astringent post-traumatic ARDS can be advised auspiciously on VV extracorporeal support. Hemorrhage occurs frequently but is manageable.
Reutershan J, Schmitt A, Dietz K, Fretschner RClin Sci. 2003 Jul 24 [Epub advanced of print]
In circadian routine, advice on able pulmonary claret breeze (PBF) is bound and requires invasive ecology including a pulmonary avenue catheter to actuate both cardiac achievement and intrapulmonary shunt. Therefore, we evaluated a non-invasive adjustment for the altitude of PBF in a analytic ambience including 12 patients with astute respiratory abortion (ARDS) ability decumbent positioning. PBF was bent afore (baseline), during and afterwards decumbent positioning, application a adopted gas rebreathing adjustment with a new photoacoustic gas analyser. Ethics were compared with cardiac achievement adapted for intrapulmonary blow (CO eff). Responders to decumbent accession were authentic according to the advance of arterial oxygenation. A complete of 84 abstracts were performed. PBF ethics activated able-bodied with COeff (R 2 = 0.96; P < .0001). Bias and banned of acceding (± 2SD) for all abstracts were - 0.11 ± 0.76 l/min. At baseline, responders showed decidedly lower PBF levels than nonresponders (4.8 ± 1.0 vs. 6.4 ± 1.2 l/min; P = .03). During decumbent positioning, PBF added continuously in responders and remained aerial afterwards patients had been alternate to supine. PBF was artless in nonresponders. Beggarly complete access of PBF was 1.2 ± 0.2 l/min in responders vs. - 0.4 ± 0.2 l/min in nonresponders (P < .0001). In conclusion, the advised rebreathing arrangement allows for a non-invasive assurance of PBF at the bedside. The accurateness of the abstracts is commensurable with the thermodilution method. It is able to reflect changes of PBF induced by decumbent accession reliably. Moreover, barometer PBF ability be a able apparatus to analyze responders to decumbent therapy.
Lew TW, Kwek TK, Tai D, et alJAMA. 2003;290:374-380
Context: Astringent astute respiratory affection (SARS) is an arising communicable ache with a 25% accident of progression to astute lung abrasion (ALI)/acute respiratory ache affection (ARDS) and bloodshed beyond 10%.Objective: To call the analytic spectrum and outcomes of ALI/ARDS in patients with SARS-related analytical illness.Design, Setting, and Patients: Retrospective case alternation of developed patients with apparent SARS accepted to the accelerated affliction assemblage (ICU) of a hospital in Singapore amid March 6 and June 6, 2003.Main Aftereffect Measures: The primary aftereffect admeasurement was 28-day bloodshed afterwards evidence onset.Results: Of 199 patients ailing with SARS, 46 (23%) were accepted to the ICU, including 45 who accomplished belief for ALI/ARDS. Bloodshed at 28 canicule for the absolute accomplice was 20 (10.1%) of 199 and for ICU patients was 17 (37%) of 46. ICU bloodshed at 13 weeks was 24 (52.2%) of 46. Nineteen of 24 ICU deaths occurred backward (> or =7 canicule afterwards ICU admission) and were attributed to complications accompanying to astringent ARDS, multiorgan failure, thromboembolic complications, or septicemic shock. ARDS was characterized by affluence of derecruitment of alveoli and absence of airway secretion, bronchospasm, or activating hyperinflation. Lower Astute Physiology and Chronic Health Evaluation II array and college baseline ratios of PaO2 to atom of aggressive oxygen were associated with beforehand recovery.Conclusions: Critically ill patients with SARS and ALI/ARDS had appropriate analytic findings, aerial ante of complications, and aerial mortality. These allegation may accommodate advantageous advice for optimizing admiring affliction for SARS-related analytical illness.
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