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polypharmacy icd 10
Baandrup L; Gasse C; Jensen VD; Glenthoj BY; Nordentoft M; Lublin H; Fink-Jensen A; Lindhardt A; Mortensen PB
OBJECTIVE: Concomitant decree of added than 1 antipsychotic abettor (antipsychotic polypharmacy) in the analysis of schizophrenia is prevalent, although monotherapy is about recommended. Bloodshed from accustomed causes is clearly added in schizophrenia, and the role of polypharmacy charcoal controversial. The cold was to investigate if antipsychotic polypharmacy is associated with the balance bloodshed from accustomed causes amid patients with schizophrenia.
METHOD: A population-based nested case-control abstraction was conducted application accommodating abstracts from January 1, 1996, to December 31, 2005, acquired from axial Danish registers. From the abstraction citizenry of 27,633 patients with ICD-8- and ICD-10-diagnosed schizophrenia or added mainly nonaffective psychoses, age-old 18-53 years, we articular 193 cases who died of accustomed causes aural a 2-year aeon and 1,937 age- and sex-matched controls. Current biologic use was authentic as at atomic 1 decree abounding aural 90 canicule afore the date of afterlife or the basis date. The abstracts were analyzed by codicillary logistic regression.
RESULTS: Accident of accustomed afterlife did not access with the cardinal of accordingly acclimated antipsychotic agents compared with antipsychotic monotherapy (no antipsychotics: adapted allowance arrangement [OR] = 1.48 [95% CI, 0.89-2.46]; 2 antipsychotics: OR = 0.91 [95% CI, 0.61-1.36]; 3 or added antipsychotics: OR = 1.16 [95% CI, 0.68-2.00]). Current use of benzodiazepine derivatives with continued abolishment half-lives (more than 24 hours) was associated with added accident of accustomed afterlife in patients with schizophrenia advised with antipsychotics (OR = 1.78 [95% CI, 1.25-2.52]).
CONCLUSIONS: Antipsychotic polypharmacy did not accord to the balance bloodshed from accustomed causes in middle-aged patients with schizophrenia. The detected added accident of afterlife associated with benzodiazepines with continued abolishment half-lives calls for added clarification.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
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