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The American Journal of Gastroenterology 102, 1042–1049 (1 May 2007) | doi:10.1111/j.1572-0241.2007.01103.x
Gilaad G Kaplan , Kevin B Laupland , Decker Butzner , Stefan J Urbanski & Samuel S Lee
OBJECTIVES: The epidemiology of primary sclerosing cholangitis (PSC) has been clumsily adjourned by population-based studies. We accordingly conducted a population-based abstraction to determine: (a) accident ante of ample and baby aqueduct PSC in adults and children, (b) the accident of anarchic bowel ache on developing PSC, and (c) patterns of analytic presentation with the appearance of alluring resonance cholangiopancreatography (MRCP). METHODS: All association of the Calgary Health Region diagnosed with PSC amid 2000 and 2005 were articular by medical records, endoscopic, analytic imaging, and anatomy databases. Demographic and analytic advice were obtained. Accident ante were bent and risks associated with PSC were appear as amount ratios (RR) with 95|[percnt]| aplomb intervals (CI). RESULTS: Forty-nine PSC patients were articular for an age- and gender-adjusted anniversary accident amount of 0.92 cases per 100,000 person-years. The accident of baby aqueduct PSC was 0.15|[sol]|100,000. In accouchement the accident amount was 0.23|[sol]|100,000 compared with 1.11|[sol]|100,000 in adults. PSC accident was agnate in Crohn's ache (CD; RR 220.0, 95|[percnt]| CI 132.4–343.7) and ulcerative colitis (UC; RR 212.4, 95|[percnt]| CI 116.1–356.5). Autoimmune hepatitis overlap was acclaimed in 10|[percnt]| of cases. MRCP diagnosed ample aqueduct PSC in one-third of cases. Delay in analysis was accepted (median 8.4 months). A boyhood had complications at diagnosis: cholangitis (6.1|[percnt]|), pancreatitis (4.1|[percnt]|), and cirrhosis (4.1|[percnt]|). CONCLUSIONS: Pediatric cases and baby aqueduct PSC are beneath accepted than developed ample aqueduct PSC. Surprisingly, the accident of developing PSC in UC and CD was similar. Autoimmune hepatitis overlap was acclaimed in a cogent boyhood of cases. The American Journal of Gastroenterology (2007) 102, 1042–1049; doi:10.1111/j.1572-0241.2007.01103.x
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