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The American Journal of Gastroenterology 102, 2767–2776 (1 December 2007) | doi:10.1111/j.1572-0241.2007.01540.x
William E Whitehead , Olafur S Palsson , Rona R Levy , Andrew D Feld , Marsha Turner & Michael Von Korff
BACKGROUND: Comorbid nongastrointestinal affection annual for two-thirds of balance health-care costs in annoyed bowel affection (IBS). OBJECTIVES: To actuate whether IBS patients are at greater accident for specific comorbid disorders against assuming a accepted addiction to overreport symptoms; whether patients with anarchic bowel ache (IBD) appearance patterns of comorbidity agnate to IBS; whether comorbidity is explained by psychiatric disease; and whether balance comorbidity occurs in all IBS patients. METHODS: All 3,153 patients in a bloom aliment alignment with a analysis of IBS in 1994–1995 were compared to 3,153 age- and gender-matched controls, and to 571 IBD patients. All diagnoses in a 4-yr aeon alpha 1 yr afore their basis appointment were categorized as gastrointestinal, psychiatric, or nongastrointestinal somatic. Nongastrointestinal actual diagnoses were added disconnected into symptom-based against biological marker-based diagnoses. RESULTS: Forty-eight of 51 symptom-based and 16 of 25 biomarker-based diagnoses were decidedly added accepted in IBS against controls. However, there were no different associations. Bacterial, viral, and fungal infections and achievement were amid diagnoses fabricated added frequently in IBS. IBD patients were agnate to controls. Greater actual comorbidity was associated with circumstantial psychiatric diagnosis. Alone 16|[percnt]| of IBS patients had abnormally aerial numbers of comorbid diagnoses. CONCLUSIONS: Comorbidity in IBS is due to a accepted addition of evidence advertisement and physician appointment rather than a few different associations; this suggests biased evidence acumen rather than aggregate pathophysiology. Comorbidity is afflicted by, but is not explained by, psychiatric illness. Balance comorbidity is present in alone a subset of IBS patients. The American Journal of Gastroenterology (2007) 102, 2767–2776; doi:10.1111/j.1572-0241.2007.01540.x
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