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Oral presentation: Monday, May 21, 9:30 a.m.Mini-symposium: 8:15-10:45 a.m.Location: Room 3005-3007 (West Building, Akin 3), Moscone Center
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Tuberculosis Increases the Accident of Lung Blight Bloodshed In The Elderly
Newswise — ATS 2012, SAN FRANCISCO – Tuberculosis apart predicts afterlife from lung blight in the elderly, according to a new abstraction from advisers in Hong Kong.
“There is a aerial accident of both tuberculosis and lung blight amid the age-old in Hong Kong,” said advance columnist Chi Chiu Leung, MBBS, adviser chest physician in the Tuberculosis and Chest Service of the Department of Bloom of Hong Kong. “In our -to-be aftereffect abstraction of a accomplice of 61,239 capacity age-old 65 years or older, we begin that alive tuberculosis was an absolute augur of lung blight afterlife afterwards acclimation for a cardinal of demographic and health-related factors.”
The after-effects will be presented at the ATS 2012 International Conference in San Francisco.
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Study capacity were enrolled from 18 Age-old Bloom Centers of the Department of Bloom in Hong Kong amid 2000 and 2003 and retrospectively cross-matched with 1993-2003 abstracts from the tuberculosis notification registry. The accomplice was followed prospectively through 2011 with causes of afterlife absolute through the territory-wide afterlife registry.
Of 61,239 abstraction subjects, 516 had alive tuberculosis above-mentioned to abstraction enrollment. During follow-up, there were 1,344 deaths from lung cancer, 910 deaths from added tobacco-related malignancies, and 2,003 deaths from non-tobacco-related malignancies.
After acclimation for gender, age, accent spoken, apprenticeship level, conjugal status, apartment situation, accessible means-tested banking abetment status, ever-smoking status, acquiescent smoking, booze use, anatomy accumulation index, abiding adverse pulmonary ache and/or asthma and ancestors history of malignancy, accepting alive tuberculosis afore abstraction acceptance was decidedly associated with afterlife from lung blight but not with afterlife anatomy the added two categories of malignancies.
“The affiliation amid tuberculosis and lung blight afterlife in age-old patients in our abstraction acceptable reflects the aftereffect of tuberculosis on the accident of this cancer,” said Dr. Leung. “Lung blight bloodshed is accretion rapidly with the crumbling citizenry in China and added Asian Countries. Our after-effects alarm for greater absorption to the achievability of lung blight in patients with a history of tuberculosis and added accessible bloom initiatives aimed at tobacco and tuberculosis control.”
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“With accumulating ability on accident factors added than cigarette smoking, attempts should be fabricated to anatomy a added absolute predictive archetypal for lung blight to ambition approaching screening activities,” Dr. Leung concluded. “Further curve of the basal mechanisms may additionally advice to analyze abeyant biologic targets for blockage and/or assay of this important baleful disease.”
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“Tuberculosis Increases The Accident Of Lung Blight Afterlife In The Elderly” (Session B20, Monday, May 21, 9:30 a.m., Room 3005-3007, Moscone Center; Abstruse 34214)
* Please agenda that numbers in this absolution may alter hardly from those in the abstract. Many of these investigations are ongoing; the absolution represents the best abreast abstracts accessible at columnist time.
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Abstract 34214Tuberculosis Increases The Accident Of Lung Blight Afterlife In The ElderlyType: Late Breaking AbstractCategory: 09.22 - Lung Cancer: Epidemiology (CP)Authors: C.C. Leung1, L. Hui2, T.H. Lam3, W.W. Yew4, W.S. Law2, C.M. Tam2; 1Department of Bloom - Hong Kong/HK, 2Department of Bloom - Hong Kong/CN, 3The University of Hong Kong - Hong Kong/CN, 4Grantham Hospital - Hong Kong/CN
Abstract BodyRationale: In Hong Kong, the anniversary tuberculosis notification amount exceeded 150/100,000 person-years amid bodies age-old 65 or above. Lung blight acme the account of all blight deaths. With the aerial accident of both conditions, a -to-be aftereffect abstraction was accordingly conducted to analyze their relationship.
Methods: A accomplice of audience age-old 65 years or above, enrolled at 18 Age-old Bloom Centers of the Department of Bloom in Hong Kong from 2000 to 2003 was accumulated and retrospectively cross-matched with the territory-wide tuberculosis notification anthology from 1993 to 2003 for alive tuberculosis notified afore the enrollment, application the character agenda cardinal as different identifier. The accomplice was again followed up prospectively through bond with the territory-wide afterlife anthology for causes of afterlife till December 31, 2011. Lung blight was authentic as primary blight of the lung with the agnate International Classification of Ache (ICD) 9 codes of 162, or ICD 10 codes of C33-C34. Added tobacco-related malignancies included blight of nasopharynx, larynx, lip, articulate cavity, esophagus, stomach, pancreas, bladder, prostate, cervix, renal corpuscle blight and astute myeloid leukemia. All capacity with doubtable or accepted blight at acceptance and those who died aural two years of aftereffect were excluded.
Results: Out of 61239 included subjects, 516 had been notified for alive tuberculosis afore enrolment. Afterwards a absolute of 612,736 person-years of follow-up, 1344, 910 and 2003 deaths occurred from lung cancer, added tobacco-related malignancies and non-tobacco-related malignancies respectively. Alive tuberculosis afore acceptance was associated with lung blight afterlife (odds ratio: 2.38, 95% aplomb level: 1.64–3.45, p<0.001) but not the added two categories of malignancies afterwards stratification by gender in Mantel-Haenszel analysis. Consistent after-effects were empiric on assay of never-smokers alone. Alive tuberculosis remained an absolute augur of lung blight afterlife (adjusted hazard ratio: 2.00, 95% aplomb level: 1.39–2.88, p<0.001) afterwards acclimation for gender, age, accent spoken, apprenticeship level, conjugal status, apartment situation, accessible means-tested banking abetment status, ever-smoking status, acquiescent smoking, booze use, anatomy accumulation index, abiding adverse pulmonary ache and / or asthma and ancestors history of blight (Table and Figure).
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Conclusion: Tuberculosis apart predicted afterlife from lung blight in the elderly, acceptable absorption its aftereffect on the accident of this high-mortality condition. With the rapidly crumbling citizenry in China, acute analytic activity for the achievability of lung blight in patients with history of tuberculosis is alleged for, alongside accessible bloom measures for tobacco and tuberculosis control.
Funded by: None reported
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